Not a drama. Webers are a bit of an inexact science when it comes to tuning, hence they love a good dyno. I had the Brisbane GURU (and I man that in all sincerity) set mine up for both cars, but they still needed the jets fine tuned on the dyno. One car had to go bigger, one car had to go smaller.
Computers are good, but EFI will never replace the sound of a good old fashioned Weber. :P